目的 探讨丹参酮Ⅱ A(Tan Ⅱ A)对柔红霉素(DNR)所致大鼠心脏毒性的预防作用,为临床肿瘤治疗提供心脏防护策略.方法 将50只4周龄心电图正常的雄性SD大鼠随机分为空白对照组、DNR组、Tan Ⅱ AⅠ组、Tan Ⅱ A Ⅱ组、Tan Ⅱ A Ⅲ组,观察不同剂量(4、8、16 mg/(kg·d)) Tan Ⅱ A对大鼠心电活动、心功能的影响.结果 Tan Ⅱ A Ⅰ、Ⅱ、Ⅲ组均未出现心律失常,左室射血分数、左室短轴缩短率明显高于与DNR组(P<0.05),且呈剂量效应关系.结论 8~16 mg/kg Tan Ⅱ A能预防和减轻DNR对大鼠心肌细胞的损伤,具有心肌保护作用.
Objective To observe the preventive and protective effect of tanshinone Ⅱ A (Tan Ⅱ A) on myocardial cell injury caused by soft erythromycin (DNR).Methods The thirty-five four-weekold healthy male SD rats were randomly divided into five groups:control group,DNR group,Tan Ⅱ A Ⅰ group,Tan Ⅱ AⅡ group,Tan Ⅱ A Ⅲ group.The effects of different doses of Tan Ⅱ A on electrical activity and heart function in rats were observed.Results Compared with the DNR group,in Tan Ⅱ A Ⅰ,Ⅱ,Ⅲ group,the electrical activity and heart function detection value reduced (P < 0.05),and showed a dose-response relationship.Conclusions Einght mg/kg to 16 mg/kg Tan Ⅱ A can prevent and mitigate the DNR-induced myocardial cell injury in rats,with myocardial protection.