Coagulation abnormalities, such as disseminated intravascular coagulation (DIC), are associated with progressive hemcrrhagic injury (PHI) following head trauma.However, the exact relationship between coagulopathy and PHI remains unclear.The present study utilized a scoring system defined by the International Society of Thrombosis and Haemostasis to investigate whether a high DIC score is predictive for PHI.This study was a multicenter prospective design involving four hospitals, a 6-month observation, and follow-up.Of 352 traumatic brain injury (TBI) patients, serial CT scan indicated approximately one third of patients developed progressive hemorrhage, which was most frequently observed in the frontal, temporal, and orbitof rontal lobes of patients with brain contusion.PHI-positive patients exhibited poor prognosis, as indicated by prolonged length of hospital/intensive care unit stay and high mortality.More importantly, a DIC score after TBI, as well as patient age and sex, could serve as predictors for PHI.In addition, DIC scores were closely associated with injury severity.Therefore, the DIC scoring system facilitated early PHI diagnosis in TBI patients, and DIC scores might serve as a valuable predictor for TBI patients with PHI.Key Words: coagulopathy; disseminated intravascular coagulation; disseminated intravascular coagulation scoring; intracranial hemorrhage; progressive hemorrhagic injury; traumatic brain injury