目的:研究鸡冠花白果止带汤对细菌性阴道病(脾虚湿热型)患者免疫功能的影响。方法:将60例细菌性阴道病患者随机分为治疗组和对照组。治疗组采用自拟方剂“鸡冠花白果止带汤”治疗;对照组采用甲硝唑口服、双唑泰栓局部给药。观察患者临床疗效并检测治疗前后血清免疫球蛋白(IgG、IgA、IgM)水平,以及外周血中 T 细胞亚群水平的变化,分析该方对细菌性阴道病(脾虚湿热型)患者的影响,初步探讨鸡冠花白果止带汤治疗细菌性阴道病的免疫调节机制。结果:1.总有效率治疗组为90%;对照组为76.67%,差异有显著性意义(P <0.05);2.治疗前后免疫球蛋白水平和 CD3+、CD4+、CD8+、CD4+/CD8+比较,差异有显著性意义(P <0.05)。结论:鸡冠花白果止带汤治疗细菌性阴道病的临床疗效优于对照组,并能提高患者的免疫功能。
Objective:To study the effect of Ji Guan Hua Bai Guo Zhi Dai Tang (JGHBGZDT)on the immune function of patients with bacterial vaginal disease.Methods:A total of 90 patients diagnosed of bac-terial vaginal disease were randomly divided into treatment group,control group 1,and control group 2.The treatment group was treated with JGHBGZDT,the control group 1 was treated with Wan Dai Tang,and the control group 2 was treated with metronidazole and Metronidazole.The clinical curative effect of treatment and testing level of immunoglobulin and T cell subgroup in peripheral blood was observed before and after the treat-ment.The effects of JGHBGZDT on bacterial vaginal disease were analyzed..Results:The total effective rate in treatment group was 90%,which was 73.33% and 76.67% in control group 1 and 2.The level of IgG, IgA,IgM,CD3 +,CD4 +and CD4 +/CD8 + were significantly higher after treatment than between before treatment and the control group (all P <0.05).Conclusion:JGHBGZDT has better effect in treatment of bacterial vaginal disease clinical curative than the control group and can improve the patient's immune func-tion.