We aim to study the properties of nuclei in the south region of $^{208}$Pb systematically, including the binding and excitation energies and electromagnetic properties, in order to predict unknown properties of these nuclei, such as isomerism, utilizing a theoretical model which describes the experimentally known properties precisely. We also address whether the $N=126$ shell closure is robust or not when the proton number decreases from $^{208}$Pb. We performed large-scale shell-model calculations with a new Hamiltonian suggested in the present work. The model space is taken as the five proton orbits within $50