To determine whether there is an increased risk of venous thromboembolism (VTE) with anti-androgen oral contraceptives containing cyproterone acetate and ethinyloestradiol.Comparison of the frequency of specific oral contraceptive use in patients aged 15 to 55 years discharged from hospital with radiologically confirmed deep vein thrombosis (DVT) and/or pulmonary embolism (PE) with the expected frequency of use derived from national prescription data.Ratio of observed frequency of specific oral contraceptive use in patients with VTE versus expected frequency of use.The rank order for observed versus expected use was anti-androgenthird-generation,second-generation,progestogen-only oral contraceptive agents with ratios of 1.93, 1.36, 0.70, and 0.39, respectively.The risk of VTE resulting in hospital admission associated with anti-androgen oral contraceptive use is at least as high as with third generation use.