Identification and Characterization of Small-Molecule Inhibitors to Selectively Target the DFG-in over the DFG-out Conformation of the B-Raf Kinase V600E Mutant in Colorectal Cancer
- Resource Type
- Authors
- Huixiang, Yao; Qun, Sun; Jinshui, Zhu
- Source
- Archiv der Pharmazie. 349(10)
- Subject
- Proto-Oncogene Proteins B-raf
Sulfonamides
Binding Sites
Indoles
Protein Conformation
Molecular Dynamics Simulation
Small Molecule Libraries
Structure-Activity Relationship
Vemurafenib
Mutation
Humans
Computer Simulation
Mutant Proteins
Colorectal Neoplasms
- Language
- ISSN
- 1521-4184
V600E is the most common mutation in the B-Raf kinase domain and the B-Raf