Pterostilbene nanoparticles with small particle size show excellent anti-breast cancer activity
- Resource Type
- Authors
- Yuan, Zou; Xiangtao, Wang; Dongdong, Bi; Jingxin, Fu; Jianwei, Han; Yifei, Guo; Li, Feng; Meihua, Han
- Source
- Nanotechnology. 32(32)
- Subject
- Mice, Inbred BALB C
Paclitaxel
Drug Compounding
Biological Availability
Antineoplastic Agents
Breast Neoplasms
Xenograft Model Antitumor Assays
Tumor Burden
Mice
Treatment Outcome
Solubility
Lecithins
Stilbenes
MCF-7 Cells
Animals
Humans
Nanoparticles
Vitamin E
Female
Particle Size
HeLa Cells
- Language
- ISSN
- 1361-6528
Pterostilbene (PTE) is known as resveratrol of the next generation and it has attracted extensive attention in recent years. PTE can inhibit the growth of a variety of tumor cells. To overcome the problem of insolubility, PTE was loaded into nanoparticles (NPs) by anti-solvent precipitation technique using soybean lecithin (SPC) and D-α-tocopheryl polyethylene glycol succinate (TPGS) as stabilizers. The obtained PTE-NPs had an average particle size of 71.0 nm, a polydispersity index (PDI) value of 0.258, and a high zeta potential of -40.8 mV. PTE-NPs can maintain particle size stability in various physiological media. The entrapment efficiency of PTE-NPs was 98.24%. And the apparently water solubility of PTE-NPs was about 53 times higher than the solubility of PTE (54.41