Globally chronic wounds are substantial health and economic concerns for patients due to the difficulties in wound healing and increasing cost of wound management. The prolonged healing time of chronic wounds is associated with the persistence of inflammation that curbs wound closure. Despite significant progress in the development of new strategies to promote wound healing, there are currently no approaches that can universally and effectively treat chronic wounds. Targeting and reducing the inflammation can promote chronic wound healing. However, for this process to be effective, the wound bed must be properly prepared and maintained using wound dressings. Since our earlier work demonstrated that extracellular vesicles (EVs) derived from placenta stem cells reduce oxidative stress and modulate inflammation, I developed here an EV-laden hydrogel dressing – HydroGEV – for chronic wound management. HydroGEV maintains the wound bed microenvironment and promotes wound healing through therapeutic EVs that are released directly at the wound site from gelatin-hydroxyphenylpropionic acid (GHPA) hydrogel. I found that placenta stem cell-derived EVs can increase the number of intercellular vesicular bodies, which are essential for intracellular communication. EVs promoted cell proliferation and migration as well as maintained functional cytoskeleton organization. These functional parameters of cells were found to be EV concertation dependent. Biomechanical properties of the hydrogel are essential to support wound healing and I showed that GHPA characterizes with tunable mechanical properties, and both mechanical properties and degradation rate of HydroGEV can be modulated. I also found that EVs do not affect the mechanical properties of the hydrogel. Furthermore, I found that the HydroGEVs provides strong support for cell adhesion proliferation and migrate hydrogels which suggests its biocompatibility and suitability for wound healing applications. Taken together, HydroGEV dressing supports wound healing and desired tissue regeneration and can potentially be considered as an effective wound management biomaterial. In the future studies, I will demonstrate and validate the applicability of the HydroGEV for wound healing in appropriate in vivo models.