Discovery and Neurobiological Modeling of Rare Genetic Variant Risk for Mental Illness
- Resource Type
- Authors
- De Jong, Job
- Source
- Subject
- SDG 3 - Good Health and Well-being
- Language
- English
The subject of this thesis is the role of rare genetic variation in the etiology of psychiatric disorders. The studies included in this work include a human genetics study on depression, a disease-modeling study for autism spectrum disorder using brain organoids, and the generation of an in vitro cellular drug-screening platform for schizophrenia. The research participants in these studies come from the genetically isolated Amish and Mennonite populations.