To explore the anti-cancer role of GABPA in the progression of gastric cancer (GC), and the underlying mechanism.Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to detect the expression pattern of GABPA in 45 pairs of GC and non-tumoral tissues. The relationship between GABPA expression and clinic pathological indicators of GC patients was analyzed. In AGS and SGC-7901 cells overexpressing GABPA, their migratory ability was determined by trans well and wound healing assay. The interaction between GABPA and its downstream target GPX1 was explored by dual-luciferase reporter assay, and their synergistical regulation on GC cell migration was finally elucidated.GABPA was downregulated in GC tissues in comparison to normal ones. Low level of GABPA predicted high incidences of lymphatic and distant metastasis in GC. Overexpression of GABPA blocked AGS and SGC-7901 cells to migrate. GABPA could target GPX1 via the predicted binding site. GPX1 was upregulated in clinical samples of GC, and negatively correlated to GABPA level. The anticancer effect of GABPA on GC relied on the involvement of GPX1.GABPA is downregulated in GC samples, which can be utilized to predict GC metastasis. Serving as a tumor suppressor, GABPA blocks GC cells to migrate by targeting GPX1.Cilj je bio da se istraži antikarcenogena uloga GABPA u progresiji raka želuca (GC) i osnovni mehanizam.Kvantitativna lančana reakcija polimeraze u realnom vremenu (kRT-PCR) je sprovedena da bi se otkrio obrazac ekspresije GABPA u 45 parova GC i netumorskih tkiva. Analiziran je odnos između ekspresije GABPA i kliničkopatoloških pokazatelja pacijenata sa GC. U ćelijama AGS i SGC-7901 koje prekomerno eksprimiraju GABPA, njihova migraciona sposobnost je određena testom transvella i zarastanja rana. Interakcija između GABPA i njegovog nizvodnog ciljanog GPKS1 istražena je testom sa dvostrukom luciferazom, a njihova sinergistička regulacija migracije GC ćelija je konačno razjašnjena.GABPA je smanjena u GC tkivima u poređenju sa normalnim. Nizak nivo GABPA predvi|a visoku incidencu limfnih i udaljenih metastaza u GC. Prekomerna ekspresija GABPA je blokirala AGS i SGC-7901 ćelije da migriraju. GABPA bi mogao da cilja GPKS1 preko predviđenog mesta vezivanja. GPKS1 je bio pojačan u kliničkim uzorcima GC i imao je negativnu korelaciju sa nivoom GABPA. Efekat GABPA protiv raka na GC oslanjao se na učešće GPKS1.GABPA je smanjena u GC uzorcima, što se može koristiti za predviđanje GC metastaza. Služeći kao supresor tumora, GABPA blokira GC ćelije da migriraju ciljajući GPKS1.