Additional file 1: Table S1. List of genes included in the five candidate neuroendocrine pathways. Table S2. Clinical characteristics of breast cancer patients from TCGA and WCH cohort, separately. Table S3. The associations between tumor mutation burden (TMB) of neuroendocrine pathways and prognosis, stratification analysis by ER status. Table S4. The associations between tumor mutation burden (TMB) of neuroendocrine pathways and prognosis with different adjustment. Table S5. The associations between tumor mutation burden (TMB) of neuroendocrine pathways and prognosis, in subsets of cohorts or exclusive gene list. Table S6. The associations between neuroendocrine pathway gene expression in tumor and normal breast tissue and prognosis, stratification analysis by ER status. Table S7. The associations between neuroendocrine pathway gene expression in tumor tissue and prognosis, in subsets of the cohorts or exclusive gene list. Table S8. The full list of genes of the glucocorticoid pathway expressed in tumor tissue associated with mutation and prognosis. Supplementary Methods include Matching of cases and controls, Whole exome sequencing and data processing and RNA-sequencing and data processing.