Outbreak of a multiresistant Klebsiella pneumoniae strain in an intensive care unit: antibiotic use as risk factor for colonization and infection
- Resource Type
- Authors
- Fernando Baquero; Purificación Ros; Antonio Oliver; Ángel Asensio; Rafael Cantón; Dolores Lasheras; Margarita Palacios; José Claudio Pérez-Díaz; Paulino González-Diego; Javier Cobo
- Source
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 30(1)
- Subject
- Microbiology (medical)
medicine.medical_specialty
Klebsiella pneumoniae
medicine.drug_class
Antibiotics
Drug resistance
Microbial Sensitivity Tests
Intensive Care Units, Pediatric
beta-Lactamases
law.invention
Disease Outbreaks
law
Risk Factors
Internal medicine
medicine
Humans
Risk factor
Intensive care medicine
Antibacterial agent
Pediatric intensive care unit
Cross Infection
biology
business.industry
Infant, Newborn
Outbreak
Infant
Drug Resistance, Microbial
biology.organism_classification
Intensive care unit
Drug Resistance, Multiple
Anti-Bacterial Agents
Klebsiella Infections
Random Amplified Polymorphic DNA Technique
Infectious Diseases
Case-Control Studies
Child, Preschool
business
- Language
- ISSN
- 1058-4838
An observational study was undertaken to describe a nosocomial outbreak caused by multiresistant Klebsiella pneumoniae (MRKP). Ten patients in the pediatric intensive care unit (ICU) at a hospital in Madrid were colonized by or infected with MRKP from October 1997 to April 1998. Thirty-two patients with MRKP-negative surveillance cultures who were admitted to the ICU during the outbreak period were selected as control patients. Random amplified polymorphic DNA analysis of MRKP isolates revealed patterns that were indistinguishable from each other. After identification of colonized patients by surveillance cultures and implementation of standard and contact precautions, the outbreak was controlled. An age