Additional file 1: Figure S1. Comparative analysis of fluorescence intensity of two cell subsets after PI staining. Figure S2. Heatmap showing the relative expression of DEGs related to cell cycle at each stage in H016-H and H016-L. Figure S3. Scanning electron microscopy observation of cell division status during fermentation process of two cell subpopulations. Figure S4. The volcano map of difference expression genes between H016-H and H016-L in fermentation process. Figure S5. Go classification of difference expression genes between H016-H and H016-L. Figure S6. KEGG classification of difference expression genes between H016-H and H016-L. Figure S7. Expression trends of genes in six clusters. The gray lines represent the expression levels of individual genes. The blue lines represent the average expression level of genes in the cluster. Figure S8. KEGG enrichment analysis of differentially expressed genes in two cell subpopulations during fermentation.