Biological measurement beyond the quantum limit
- Resource Type
- Authors
- Vincent Ricardo Daria; Jiri Janousek; Michael A. Taylor; Warwick P. Bowen; Boris Hage; Hans-A. Bachor; Joachim Knittel
- Source
- Scopus-Elsevier
- Subject
- FOS: Physical sciences
Optics
Quantum metrology
Electronic engineering
Physics - Biological Physics
Limit (mathematics)
Quantum
Physics
Quantum optics
Quantum Physics
business.industry
Quantum limit
Quantum noise
technology, industry, and agriculture
Shot noise
equipment and supplies
Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biophotonics
Light intensity
Biological Physics (physics.bio-ph)
Temporal resolution
Lipid particle
Quantum Physics (quant-ph)
business
Optics (physics.optics)
Physics - Optics
Squeezed coherent state
- Language
- ISSN
- 1749-4893
1749-4885
Quantum metrology allows high sensitivity measurements to proceed with a lower light intensity than classically possible [1]. An important frontier for this technology is in biological measurements, where photochemical interactions often disturb biological processes and can damage the specimen [2]. Here we report the first demonstration of biological measurement with precision surpassing the quantum noise limit [3]. This was enabled through the development of a new microscopy system which extended previous methods used to track the motion of highly reflective mirrors with non-classical light to measurements of microscopic particles with non-paraxial fields (see Fig. 1). Biological dynamics in the critical Hz-kHz frequency range were made accessible by applying a quantum optical lock-in technique for the first time. This straightforward technique allowed quantum enhancement over a frequency range which reached as low as the range reported for squeezed light sources developed for gravity wave interferometers [4].