Progressive supranuclear palsy-like phenotype associated with bilateral hypoxic-ischemic striopallidal lesions
- Resource Type
- Authors
- Simon Shields; Niall Quinn; Hee Tae Kim; Kailash P. Bhatia
- Source
- Movement Disorders. 20:755-757
- Subject
- Male
Pathology
medicine.medical_specialty
Ischemia
Thoracic aortic aneurysm
Apraxia
Progressive supranuclear palsy
Aortic aneurysm
medicine
Humans
Aged
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
Hypoxia (medical)
medicine.disease
Magnetic Resonance Imaging
Corpus Striatum
eye diseases
Supranuclear gaze palsy
Neurology
Hypoxia-Ischemia, Brain
Supranuclear Palsy, Progressive
Neurology (clinical)
medicine.symptom
business
- Language
- ISSN
- 1531-8257
0885-3185
A progressive supranuclear palsy (PSP)-like syndrome due to vascular or anoxic brain insult is rare. We describe a 65-year-old man with a progressive PSP-like phenotype associated with hypoxic-ischemic bilateral striopallidal lesions, secondary to rupture of and subsequent surgery for a thoracic aortic aneurysm. After early extrapyramidal features, 10 months later he started to fall, and developed levator inhibition. A supranuclear gaze palsy for downgaze was documented 5.5 years after the insult.