Long noncoding RNA Linc01612 represses hepatocellular carcinoma progression by regulating miR-494/ATF3/p53 axis and promoting ubiquitination of YBX1
- Resource Type
- Authors
- Pengpeng, Liu; Qiu, Zhong; Youai, Song; Deliang, Guo; Dong, Ma; Baiyang, Chen; Jianwei, Lan; Quanyan, Liu
- Source
- International Journal of Biological Sciences. 18:2932-2948
- Subject
- Activating Transcription Factor 3
Carcinoma, Hepatocellular
Liver Neoplasms
Ubiquitination
Cell Biology
Applied Microbiology and Biotechnology
Gene Expression Regulation, Neoplastic
MicroRNAs
Transcription Factor 3
Cell Line, Tumor
Disease Progression
Humans
RNA, Long Noncoding
Y-Box-Binding Protein 1
Tumor Suppressor Protein p53
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Cell Proliferation
Developmental Biology
- Language
- ISSN
- 1449-2288
Long noncoding RNAs (lncRNAs) play an important role in the progression of hepatocellular carcinoma (HCC). Linc01612 is a novel lncRNA that function remains unknown in the progression of cancers, including HCC. In this study, we discovered that Linc01612 is significantly down-regulated in HCC tissues than in non-tumor tissues and correlated with poor prognosis. Linc01612 mainly localizes in the cytoplasm and functions as a tumor suppressor by repressing the growth and metastasis of hepatoma cells