Personalized Therapy and Liquid Biopsy—A Focus on Colorectal Cancer
- Resource Type
- Authors
- Léa Veyrune; Sotirios Georgios Popeskou; Muriel Mathonnet; Niki Christou
- Source
- Journal of Personalized Medicine, Vol 11, Iss 630, p 630 (2021)
Journal of Personalized Medicine
- Subject
- 0301 basic medicine
Oncology
medicine.medical_specialty
liquid biopsy
Colorectal cancer
business.industry
Personalized treatment
Medicine (miscellaneous)
Cancer
Review
medicine.disease
Response to treatment
personalized treatment
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
030220 oncology & carcinogenesis
Internal medicine
medicine
cancers
Medicine
Liquid biopsy
Personalized therapy
business
- Language
- English
- ISSN
- 2075-4426
(1) Background: Resistance mechanisms represent a barrier to anti-cancer therapies. Liquid biopsies would allow obtaining additional information in order to develop targeted therapies to thwart the resistance phenomena but also to follow in time real response to treatment and be able to adapt it the most quickly possible way in case of resistance. (2) Methods: herein we summarize the different liquid biopsies which are currently under research; we then review the literature and focalize on one of their potential roles: the theranostic one and especially in the cases of colorectal cancers. (3) Results: few studies targeting liquid biopsy as a potential tool to adapt cancer treatments are present in the literature and encompass few patients. (4) Conclusions: further research is needed to prove the efficiency of LB. Indeed, it seems a promising tool to guide treatment by targeting actionable mutations with detection of resistant mutations.