Optimization of image sampling rate to lower the radiation dose of dynamic myocardial CT perfusion
- Resource Type
- Authors
- Mathias Sørgaard; Jesper J. Linde; Mathias B. Møller; Lars Køber; Klaus F. Kofoed
- Source
- Journal of Cardiovascular Computed Tomography. 15:457-460
- Subject
- Image sampling
Heartbeat
Computed Tomography Angiography
Perfusion scanning
Coronary Artery Disease
030204 cardiovascular system & hematology
Radiation Dosage
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Sampling (signal processing)
Predictive Value of Tests
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Lead (electronics)
Equivalence (measure theory)
business.industry
Radiation dose
Myocardial Perfusion Imaging
Blood flow
Perfusion
Tomography, X-Ray Computed
Cardiology and Cardiovascular Medicine
Nuclear medicine
business
- Language
- ISSN
- 1934-5925
Background Dynamic myocardial CT perfusion (CTP) has emerged as a potential strategy to combine anatomical and functional evaluation in a single modality. However, this method results in a high radiation dose. Methods Dynamic CTP was performed in 56 patients with suspected or known ischemic heart disease of whom 48 had complete CT-data. Datasets with reduced sampling rate of 2- and 3 RR-intervals (2RR and 3RR) were constructed post hoc. Myocardial blood flow (MBF) estimates from the 2RR and 3RR datasets were compared with estimates based on the full dataset (1RR) using the two one-sided test of equivalence for paired samples. Results Significant equivalence was found for rest MBFLV (p Conclusion MBF can be quantitated with dynamic CTP using a sampling strategy of one volume for every second heartbeat. This strategy could lead to a significant reduction in radiation dose.