Background Despite strong evidence of heritability, few studies have attempted to unveil the genetic underpinnings of testosterone levels. Objective To identify testosterone-associated loci in a large study and assess their biological and clinical implications. Design, setting, and participants The participants were men from the UK Biobank. A two-stage genome-wide association study (GWAS) was first used to identify/validate loci for low testosterone (LowT
Take Home Message In a large population-based cohort, we conducted a genome-wide association study to determine the heritability of low testosterone. We discovered 141 loci associated with low testosterone and potential candidate genes, and created a novel genetic risk score to predict low testosterone.