Disseminated Nannizziopsis Infection in an Adolescent With a STAT1 Mutation
- Resource Type
- Authors
- Dinesh Rakheja; Zachary M Most; Andrew Gelfand; Tiffany J. Lieu; Laura M. Filkins; Jeffrey S. Kahn; Rory Nicolaides
- Source
- Open Forum Infectious Diseases
- Subject
- 0301 basic medicine
Nannizziopsis
030106 microbiology
DNA sequencing
03 medical and health sciences
STAT1
Cuboid bone
medicine
voriconazole
Pathogen
immunocompromised host
Voriconazole
biology
business.industry
Osteomyelitis
medicine.disease
biology.organism_classification
Virology
030104 developmental biology
Infectious Diseases
AcademicSubjects/MED00290
Oncology
fungal infections
Failure to thrive
Mutation (genetic algorithm)
Brief Reports
medicine.symptom
business
medicine.drug
- Language
- English
- ISSN
- 2328-8957
An adolescent with failure to thrive developed cuboid bone osteomyelitis and brain abscesses. Mold isolated from both locations was identified by universal genetic sequencing as Nannizziopsis spp, which is typically a pathogen of reptiles. The patient was subsequently diagnosed with a STAT1 mutation and was successfully treated.