Cryopreservation of ovarian tissue in breast cancer patients: 10 years of experience
- Resource Type
- Authors
- Cesare Battaglia; Stefano Venturoli; Raffaella Fabbri; Gianandrea Pasquinelli; Roberto Paradisi; Valentina Magnani; Rossella Vicenti; Isabella Parazza; Maria Macciocca
- Source
- Future Oncology. 8:1613-1619
- Subject
- Adult
endocrine system
Cancer Research
Pathology
medicine.medical_specialty
Breast Neoplasms
Cryopreservation
Young Adult
Follicle
Breast cancer
Ovarian Follicle
Stroma
BREAST CANCER
Follicular phase
follicular density
medicine
Humans
Ovarian tissue cryopreservation
Fertility preservation
ovarian tissue cryopreservation
business.industry
Ovarian tissue
Ovary
Age Factors
Fertility Preservation
General Medicine
medicine.disease
histological analysi
Oncology
Female
business
- Language
- ISSN
- 1744-8301
1479-6694
Aim: To present a decade of experience with ovarian tissue cryopreservation in breast cancer patients. Materials & methods: The safety of the procedure was histologically evaluated before and after freezing in 94 patients. Out of 94 patients, 48 prechemotherapy patients were randomly selected to determine stroma and follicle preservation and follicular density. Results: The ovarian tissue from 94 patients did not identify any micrometastases. After cryopreservation, morphology of the ovarian tissue and density of healthy follicles were similar in fresh and frozen tissue. Follicular density decreased with the increasing age of patients in both fresh and frozen tissue (p < 0.0001). A variation in follicular density was observed between fresh and frozen tissue (p < 0.05). Conclusion: These results suggest that ovarian tissue cryopreservation is highly feasible for preserving the fertility of young breast cancer patients.