Pregnancy in fanconi anaemia with bone marrow failure: a case report and review of the literature
- Resource Type
- Authors
- Flavia Sorbi; Massimiliano Fambrini; Alessandro Di Filippo; Federico Mecacci
- Source
- BMC Pregnancy and Childbirth
- Subject
- Pancytopenia
Bacteremia
Case Report
Antenatal care
0302 clinical medicine
Obstetrics and gynaecology
Fanconi anemia
Pregnancy
hemic and lymphatic diseases
Campylobacter Infections
Diet, Diabetic
Obstetrics and Gynaecology
Insulin
Pregnancy Complications, Infectious
Bone Marrow Diseases
Fanconi Anaemia
Escherichia coli Infections
High-risk pregnancy
Obstetrics and Gynecology
030219 obstetrics & reproductive medicine
Obstetrics
Staphylococcal Infections
Anti-Bacterial Agents
Female
Erythrocyte Transfusion
Adult
medicine.medical_specialty
Neutropenia
Platelet Transfusion
Malignancy
03 medical and health sciences
medicine
Humans
Hypoglycemic Agents
business.industry
Cesarean Section
Pregnancy Complications, Hematologic
Bone marrow failure
medicine.disease
Thrombocytopenia
Transplantation
Diabetes, Gestational
Fanconi Anemia
Puerperal Infection
business
030215 immunology
- Language
- English
- ISSN
- 1471-2393
Background Fanconi anaemia is a rare inherited disease characterized by congenital abnormalities, progressive bone marrow failure and predisposition to malignancy. Successful pregnancies in transplanted patients have been reported. In this paper we will describe the pregnancy of a patient with Fanconi anaemia without transplantation. Case presentation A 34-year-old nulliparous woman with Fanconi anaemia was referred to our institution. Pregnancy was complicated by progressive pancytopenia and two severe infections. C-section was performed at 36 weeks. Both infant and mother are well. Conclusion Successful pregnancy in a Fanconi anaemia patient with bone marrow failure is possible. The mode of delivery in patients with bone marrow failure should be determined by obstetric indications. The case highlights the safe outcome of the pregnancy with strict clinical and laboratory control by a multidisciplinary team.