Spinal cord compression after radiolabeled metaiodobenzylguanidine analogue therapy in advanced malignant insulinoma
- Resource Type
- Authors
- Adelina Sanches; Marcony Queiroz Andrade; Alina Coutinho Rodrigues Feitosa; Melba Moura; Dálvaro Oliveira de Castro Júnior; José Rocha Filho
- Source
- Archives of Endocrinology and Metabolism, Vol 59, Iss 2, Pp 186-189
- Subject
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
lcsh:Medicine
Bone Neoplasms
Disease
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Fatal Outcome
Spinal cord compression
Slow progression
medicine
Humans
Multimodal treatment
Surgical treatment
Aged
lcsh:RC648-665
business.industry
lcsh:R
Liver Neoplasms
Late stage
medicine.disease
Combined Modality Therapy
Malignant insulinoma
Surgery
Pancreatic Neoplasms
3-Iodobenzylguanidine
Lymphatic Metastasis
Female
Insulinoma
Radiology
Radiopharmaceuticals
business
Spinal Cord Compression
- Language
- ISSN
- 2359-3997
Malignant insulinomas are frequently diagnosed at a late stage. Medical management is necessary to slow progression of the disease and control of hypoglycemic symptoms when cure by surgical treatment is not possible. Multimodal treatment, in these cases, has been used with variable clinical response. We describe a 68-yr-old woman who presented response failure to usual treatment and was alternatively treated with radiolabeled metaiodobenzylguanidine ([131I]-MIBG) analogue therapy with development of neurologic complications. We also present a review of the current role of [131I]-MIBG treatment in insulinomas.