Background Obesity in older adults contributes to increasing comorbidities and decreased quality of life. There is limited research including older adult perspectives on weight loss. Objective The purpose of this qualitative study was to gain a better understanding of older adults’ perceptions and experiences related to weight loss immediately following a 6-month weight loss intervention. Design A qualitative research design utilizing semi-structured interviews conducted as part of a larger research study exploring weight loss and/or aerobic exercise on muscle inflammation. Participants /setting A sample of community-based older adults (n=11) in Southwestern Ohio were recruited from September 2018 through August 2019 following completion of a 6-month weight loss intervention. Eligible participants were >58 years, BMI > 27 kg/m2, sedentary with no cognitive deficits. Exclusions included cancer, heart disease, diabetes, and tobacco use. Analysis Interviews were recorded, transcribed verbatim, and analyzed using thematic analysis. Descriptive statistics were used for demographic data. Results Three emergent themes included barriers and challenges to weight loss, which included caregiving roles, challenges with increasing protein intake, and ambivalence to change; personal strategies for success (portion control and meal flexibility); and external strategies for success (visual graphs as feedback measures, alternate measures of success, and social support). Conclusions The results of this qualitative study provide insight into older adults' experiences with weight loss which may be considered when designing weight management interventions. However, more research is needed to examine strategies to address the challenges identified by participants in this research study. Future qualitative research should also focus on weight loss perspectives of older adults in other racial and ethnic groups.