Supplementary methods. Table S1. Multivariate analyses adjusting for clinical prognostic covariates. Figure S1. ExteNET: CONSORT diagram of the correlative cohort. Figure S2. Kaplan-Meier plots of 5-year invasive disease-free survival for PIK3CA-altered vs wild-type tumors in the placebo arm of the correlative cohort, for assessment of prognostic effect. Figure S3. Kaplan-Meier plot of 5-year invasive disease-free survival for PIK3CA wild-type patients in the correlative cohort. (DOCX 404 kb)