Additional file 1: Figure S1. Characterization of the transgenic mouse lines. (A) Flowchart of experimental setup including tamoxifen injection, exposure duration and endpoint measurements. (B) Hematocrit levels in SMMHC-CreERT2; HIF-1��fl/fl (blue), GFAP-CreERT2; HIF-1��fl/fl (light green) and GLAST-CreERT2;HIF-1��fl/fl (dark green) mice treated with oil (Ctrl) or tamoxifen (LoF) after exposure to 96 h normoxia (Nx, 21% O2) or hypoxia (Hx, 8% O2). Two-way ANOVA, mean �� SD, n = 3���8, ****p