Additional file 1. Supplementary Figure 1: A representative pictograph shows trilineage differentiation of tissue specific hMSCs (a) A panel shows osteocyte differentiation which is confirmed by alizarin red staining, (b) Adipocyte���s differentiation shows positivity for oil red ���o��� staining. (c) Chondrocyte���s differentiation shows positivity for Alcian blue staining. Scale bar 50 ��m. Supplementary Figure 2: A representative pictograph showing the morphology of tissue specific hMSCs upon pre-conditioning of different Dex concentrations at 24 h & 48 h. Scale bar 100 ��m. Supplementary Figure 3: A representative pictograph shows scratch assay in tissue specific hMSCs (a-d) Scratch at 0 h represents the initial day whereas closure of the area was taken at 12 h and 24 h and % open area was calculated. Scale bar 100 ��m. Supplementary Figure 4: (a���d) Representative images shows intracellular SOX-2 expression level in BM-MSCs, whereas (e) Bar graph represent the relative intensity for SOX-2 expression after pre-conditioning with different Dex concentrations at 48 h, where 2000 ng/ml shows the significant expression level. (f���i) Representative images shows intracellular SOX-2 expression level in AD-MSCs, (j) Bar graph represent the relative intensity for SOX-2 expression after pre-conditioning with different Dex concentrations at 48 h and shows dose-dependent increase in expression level, (k���n) Representative images shows intracellular SOX-2 expression level in DP-MSCs, whereas (o) Bar graph represent the relative intensity for SOX-2 expression after pre-conditioning with different Dex concentrations at 48 h, (p���s) Representative images shows intracellular SOX-2 expression level in UC-MSCs, whereas (e) Bar graph represent the relative intensity for SOX-2 expression after pre-conditioning with different Dex concentrations at 48 h, shows dose-dependent increase in expression level. Scale bar 200 ��m. Supplementary Figure 5: (a���d) Representative images shows intracellular NANOG expression level in BM-MSCs,whereas (e) Bar graph represent the relative intensity for NANOG expression after pre-conditioning with different Dex concentrations at 48 h, where 1000 ng/ml shows the significant expression level. (f���i) Representative images shows intracellular NANOG expression level in AD-MSCs, (j) Bar graph represent the relative intensity for NANOG expression after pre-conditioning with different Dex concentrations at 48 h and where 1000 ng/ml shows the significant expression level, (k���n) Representative images shows intracellular NANOG expression level in DP-MSCs, whereas (o) Bar graph represent the relative intensity for NANOG expression after pre-conditioning with different Dex concentrations at 48 h, where 3000 ng/ml shows the significant expression level (p���s) Representative images shows intracellular NANOG expression level in UC-MSCs, whereas (e) Bar graph represent the relative intensity for NANOG expression after pre-conditioning with different Dex concentrations at 48 h, shows dose-dependent increase in expression level. Scale bar 200 ��m. Supplementary Figure 6: (a���d) Representative images shows intracellular OCT-4 expression level in BM-MSCs, whereas (e) Bar graph represent the relative intensity for OCT-4 expression after pre-conditioning with different Dex concentrations at 48 h, where 3000 ng/ml shows the significant expression level. (f���i) Representative images shows intracellular OCT-4 expression level in AD-MSCs, (j) Bar graph represent the relative intensity for OCT-4 expression after pre-conditioning with different Dex concentrations at 48 h and where 3000 ng/ml shows the significant expression level, (k���n) Representative images shows intracellular OCT-4 expression level in DP-MSCs, whereas (o) Bar graph represent the relative intensity for OCT-4 expression after pre-conditioning with different Dex concentrations at 48 h, where 2000 ng/ml shows the significant expression level (p���s) Representative images shows intracellular OCT-4 expression level in UC-MSCs, whereas (e) Bar graph represent the relative intensity for OCT-4 expression after pre-conditioning with different Dex concentrations at 48 h, where 1000 ng/ml shows the significant expression level. Scale bar 200 ��m.