Additional file 1 of Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure
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- Lépine, Matthieu; Douceau, Sara; Devienne, Gabrielle; Prunotto, Paul; Lenoir, Sophie; Regnauld, Caroline; Pouettre, Elsa; Piquet, Juliette; Lebouvier, Laurent; Hommet, Yannick; Maubert, Eric; Agin, Véronique; Lambolez, Bertrand; Cauli, Bruno; Ali, Carine; Vivien, Denis
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Additional file 1: Figure S1. Characterization of a tPA-reporter viral construct in the dentate gyrus. Figure S2. Plat-GFP reporter expression in the cortex after LPS treatment. Figure S3. Plat-GFP reporter expression in excitatory neurons in the cortex. Figure S4. tPA mRNA is expressed in PV interneurons enwrapped with PNNs. Figure S5. Conditional depletion of tPA in PV interneurons. Figure S6. PNN-like structures in vitro. Figure S7. Interneuron-derived tPA promotes PNN degradation through plasmin. Figure S8. tPA/plasmin mediated PNNs degradation is MMP-independent. Table S1. Sequences of PCR primers. Supplementary materials and methods.