Agreement between left ventricular ejection fraction assessed in patients with gated IQ-SPECT and conventional imaging
- Resource Type
- Authors
- Gianmauro Sacchetti; Alessandro Carriero; Lucia Leva; Roberta Matheoud; Marco Brambilla
- Source
- Journal of Nuclear Cardiology. 27:1714-1724
- Subject
- Adult
Male
Gated SPECT
Coronary Artery Disease
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
law.invention
Iq spect
03 medical and health sciences
Organophosphorus Compounds
0302 clinical medicine
law
Image Processing, Computer-Assisted
Humans
Medicine
Radiology, Nuclear Medicine and imaging
In patient
Statistical analysis
Analysis method
Aged
Gamma camera
Aged, 80 and over
Ejection fraction
business.industry
Limits of agreement
Myocardial Perfusion Imaging
Reproducibility of Results
Stroke Volume
Organotechnetium Compounds
Middle Aged
Female
Radiopharmaceuticals
Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography
Cardiology and Cardiovascular Medicine
business
Nuclear medicine
Algorithms
Software
- Language
- ISSN
- 1532-6551
1071-3581
The aim of the study was to assess the agreement between the left ventricular ejection fraction (LVEF) values obtained with IQ-SPECT and those obtained with a conventional gamma camera equipped with low-energy high-resolution (LEHR), considered as the method of reference. Gated-stress MPI using 99mTc-tetrofosmin was performed in 55 consecutive patients. The patients underwent two sequential acquisitions (Method A and B) performed on Symbia-IQ SPECT with different acquisition times and one (Method C) on a Ecam SPECT equipped with LEHR collimators. The values of the different datasets were compared using the Bland-Altman analysis method: the bias and the limits of agreement (LA) were estimated in a head-to-head comparison of the three protocols. In the (Method A-Method C) comparison for LVEF, the bias was 3.8% and the LAs ranged from − 9.3% to 16.8%. The agreement was still lower between Method B and C, whilst only slightly improved when Methods A and B were compared. The wide amplitude in LA intervals of about 30% indicates that IQ and LEHR GSPECT are not interchangeable. The values obtained with IQ-SPECT should only be used with caution when evaluating the functional state of the heart.