Additional file 1: Table S1. Primer Sequence of Each Gene Locus and PCR Reaction Conditions. Table S2. Primer Sequence of Each Gene Locus and PCR Reaction Conditions. Table S3. The Genotype and Allele Distributions of ACE, ACE2 and CYP11B2 Distribution in the EH Group and Control Group. Table S4. Analysis of the Multiplicative Interactions Between ACE, ACE2 and CYP11B2. Table S5. Analysis of Multiplication Interactions Between ACE, ACE2, CYP11B2 and Noise. Figure S1. The combined model of gene���noise interactions.