Tissue repair is a natural process occurring any time the skin is injured. Repair is achieved through different successive phases: inflammation, formation of granulation tissue, forma‐ tion of the extracellular matrix (ECM), and remodeling. ECM plays an important role in tis‐ sue regeneration representing the principal component of the dermal skin layer. The composition of ECM includes proteoglycans, hyaluronic acid, collagen, fibronectin and elas‐ tin. As well as providing a structural support for cells, some components of the ECM bind to growth factors, creating a reservoir of active molecules that can be rapidly mobilized follow‐ ing injury to stimulate cell proliferation and migration [1].