The dynamic RNA modifications were orchestrated by a series of enzymes, namely "writer", "reader" and "eraser", which can install, recognize and remove the modifications, respectively. However, only a very small number of experimentally validated RNA modification enzymes have been identified and reported. Therefore, there is an urgent need to develop a database to deposit RNA modification enzymes. In the present work, we developed the RNAME database (https://chenweilab.cn/rname/) to provide a comprehensive resource for RNA modification enzymes. The current version of RNAME deposits more than 21,000 manually curated RNA modification enzymes, which are from 456 species and covers the 7 common kinds of RNA modifications (i.e., adenosine to inosine, N