VEGF-A, HGF, and vimentin are increased in GBM patient plasma and correlate with disease aggressiveness. A, Proximity extension assay (PEA) immunoprofiling of proteins in plasma from GBM patients (N = 68) and healthy controls (N = 16) shows that several proteins increased by LD loading in vitro (as shown in Fig. 2a) are also increased in GBM patient plasma. Data shown are corrected values (for age and sex) presented as the mean linear fold change. *P ≤ 0.05. B-D, 1-year survival of GBM patients with high or low expression levels of VEGF-A (B), vimentin (VIM) (C) and HGF (D). (PDF 45 kb)