Background The extent to which the risk of estrogen receptor (ER)-specific breast cancer is associated with ER status of breast cancer and other cancers among first-degree relatives (FDRs) is unclear. Methods This population-based cohort included 464,707 cancer-free women in Stockholm, Sweden, during 1978-2019. For both ER-negative and ER-positive breast cancers, we estimated hazard ratio (HR) associated with ER status of female FDRs with breast cancer and of other cancers in all FDRs. Associations between ER-negative and ER-positive by family cancer history were estimated using logistic regression in a case-only design. Results Women with familial ER-positive breast cancer had 1.87-times (95% confidence interval [CI] 1.77-1.97) higher risk of ER-positive subtype, while the corresponding HR for ER-negative was 2.54 (2.08-3.10) when having familial ER-negative breast cancer. The risk increased with an increasing number of female FDRs having concordant subtypes and younger age at diagnosis (Ptrend Conclusions Risk of ER-specific breast cancer differs according to ER status of female FDRs with breast cancer, and some other cancers of FDRs. This family history information should be considered in the individual risk prediction for ER subtypes.