COVID-19 impact on liver: inter-organ cross-talk in an acute inflammation
- Resource Type
- Authors
- Rajesh K. Yadav; Dipesh Kumar Yadav; Liang Tingbo; Alina Singh; huang xing; Bai Xue Li
- Source
- Journal of Patan Academy of Health Sciences. 8:38-46
- Subject
- Coronavirus disease 2019 (COVID-19)
business.industry
viruses
Immunology
medicine
Inflammation
medicine.symptom
business
- Language
- ISSN
- 2091-2757
2091-2749
Since coronavirus disease 2019 (COVID-19) has been a new disease, very less is known about the disease, and guidance for the treatment are often being made on the basis of an experiences or expert opinions. Now it is known that COVID-19 is caused by a new Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus which elicit infection to the cells by binding of the spike protein to angiotensin converting enzyme 2 (ACE2). Given the high transmissibility rate of the SARS-Cov-2 virus and known to have cytokine dysregulation by inducing an immune-mediated systemic inflammation, patients with underlying liver disease might be at an increased risk of severe infection and death. Here we report different mechanisms based on the organ cross-talk and other causes that how COVID-19 patients are prone to have liver injury.