18 F‐FDG PET / CT brain glucose metabolism as a marker of different types of depression comorbidity in chronic heart failure patients with impaired systolic function
- Resource Type
- Authors
- Maria Kallergi; Dimitrios Th. Kremastinos; Vassiliki Lyra; Gerasimos Filippatos; Emmanouil Rizos; John Parissis; Sofia Chatziioannou
- Source
- European Journal of Heart Failure. 22:2138-2146
- Subject
- medicine.medical_specialty
Ejection fraction
business.industry
Beck Depression Inventory
Systolic function
030204 cardiovascular system & hematology
Carbohydrate metabolism
medicine.disease
Comorbidity
03 medical and health sciences
0302 clinical medicine
Heart failure
Internal medicine
medicine
Cardiology
Fdg pet ct
Cardiology and Cardiovascular Medicine
business
Depression (differential diagnoses)
- Language
- ISSN
- 1879-0844
1388-9842
Aims Depression is an important issue in heart failure (HF). The study investigated whole-brain and regional brain glucose metabolism in HF patients and its association with depression comorbidity. Methods and results Twenty-nine hospitalized patients with symptomatic systolic HF (left ventricular ejection fraction 0.93) or 'real' (≤0.93) depression. Conclusion Heart failure patients with more severe disease showed whole-brain and regional brain hypometabolism in 18 F-FDG PET/CT. Depressed HF patients (Beck Depression Inventory score >13) exhibited different metabolic patterns that could be used to differentiate between 'epiphenomenal' and 'real' depression. Namely, presence of whole-brain hypometabolism suggested 'epiphenomenal' depression, whereas absence suggested 'real' depression. Presence of significant relative regional brain hypometabolism enhanced the likelihood of 'real' depression diagnosis.