Labeled bile acids I: Synthesis of 18O-methyl hydroxy-5β-cholan-24-oates
- Resource Type
- Authors
- Chang Yon Byon; Warren G. Anderson; Marcel Gut; Charles R. Eck
- Source
- Journal of Labelled Compounds and Radiopharmaceuticals. 21:59-64
- Subject
- chemistry.chemical_classification
Ketone
Bile acid
Hydride
medicine.drug_class
Organic Chemistry
Acetal
digestive system
Biochemistry
Analytical Chemistry
chemistry.chemical_compound
Hydrolysis
chemistry
Drug Discovery
medicine
Organic chemistry
Radiology, Nuclear Medicine and imaging
Spectroscopy
- Language
- ISSN
- 0362-4803
The incorporation of 18O into the 3-hydroxyl of bile acids has been accomplished by hydrolysis of the acetal corresponding to the 3-oxo bile acid with H2O, followed by hydride reduction of the ketone to the labeled hydroxyl function.