The Effect of Luteinising Hormone Suppression in In Vitro Fertilisation Antagonist Cycles
- Resource Type
- Authors
- Jessie Wai Leng Phoon; Jill Cheng Sim Lee; John Carson Allen; Sadhana Nadarajah; Jerry Kok Yen Chan; Jody Paige Goh; Shuling Liu; Xiang Wen Ng
- Source
- Reproductive Sciences. 28:3164-3170
- Subject
- 0301 basic medicine
medicine.medical_specialty
media_common.quotation_subject
medicine.medical_treatment
Ovarian hyperstimulation syndrome
Controlled ovarian hyperstimulation
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
Ganirelix
Ovulation
Menstrual cycle
media_common
030219 obstetrics & reproductive medicine
In vitro fertilisation
business.industry
Antagonist
Obstetrics and Gynecology
medicine.disease
030104 developmental biology
Endocrinology
Ovulation induction
business
hormones, hormone substitutes, and hormone antagonists
medicine.drug
- Language
- ISSN
- 1933-7205
1933-7191
Use of GnRH antagonists in IVF stimulation protocols shortens controlled ovarian hyperstimulation (COH) and reduces the risk of ovarian hyperstimulation syndrome (OHSS). However, profound reduction in LH levels has been associated with use of GnRH antagonists. This study aims to determine if LH suppression during GnRH antagonist cycles results in poorer IVF outcomes. This was a prospective pilot longitudinal study where serum LH levels were measured on day 2/3 of the menstrual cycle before COH, 1/2 days following institution of GnRH antagonist and at the day of ovulation trigger. A threshold of LH