Usage of Enzymes in the Therapy of Chronic Wounds. Preliminary Results
- Resource Type
- Authors
- Peter Nedkov; Dragomir Dardanov; P. Christov; Iovcho Topalov
- Source
- Proceeding of the Bulgarian Academy of Sciences. 66
- Subject
- medicine.medical_specialty
Multidisciplinary
integumentary system
business.industry
Proteolytic enzymes
Healed wounds
Surgery
law.invention
Randomized controlled trial
law
Active component
Medicine
Single institution
business
- Language
- ISSN
- 1310-1331
We present our preliminary results of clinical application of two original enzyme-derived topical preparations, Neprolysin and Post-Neprol, on patients with chronic wounds. Neprolysin is a preparation containing a purified proteolytic enzyme possessing strong activity in the neutral pH-area. The main active component of Post-Neprol is collagen hydrolysate. The aim of the study is to assess the safety and efficacy of local enzymatic treatmentof chronic wounds. For a period of 3 years, in a single institution 56 patients suffering from chronic wounds were treated. Twenty-two % of the patients were discharged with fully epithelized healed wounds. The rest (78%) of the patients were discharged with continuously healing non-infected wounds. It was found that the application of Neprolysin and Post-Neprol in complex treatment of patients with chronic wounds is safe and promises effectiveness. Control randomized clinical trials were warranted.