Parkinson’s disease (PD) has a large heritable component and genome-wide association studies to date have identified over 90 variants associated with PD, providing deeper insights into the disease biology. However, there have not been large-scale rare variant analyses for PD. To address this gap, we investigated the rare genetic component of PD at minor allele frequencies GBAandLRRK2, have been previously implicated as risk factors for PD, we identify potential novel associations forB3GNT3, AUNIP, ADH5, TUBA1B, OR1G1, CAPN10, andTREML1. Of these,B3GNT3andTREML1provide new evidence for the role of neuroinflammation in PD. To date, this is the largest analysis of rare genetic variation in PD.