This global health research project focuses on a neglected condition (albinism) and the health inequities and human rights violations faced by mothers who give birth to a baby with albinism. For many women, the delivery marks the beginning of a sequelae of life-altering societal responses that ultimately prevent her and her baby from the full enjoyment of their human rights. Giving birth to a baby with albinism can precipitate abandonment by family and community, intimate partner violence, and precarity. A synthesis of the evidence regarding the experiences surrounding the birth of a baby with albinism for family members and their carers in Africa is needed to inform research and practice. Specifically, this synthesis will support a broader ongoing study exploring how the perinatal experiences of mothers who give birth to a baby with albinism can be improved through health services, health professions education, and the development of equity-oriented and contextually relevant educational strategies, with the overarching aim of promoting, protecting, and fulfilling their human rights. This evidence synthesis is the first phase of four of our study (to read more: www.motheringandalbinism.com). As we are taking a participatory approach, it will facilitate an interdisciplinary dialogue with our intersectoral network to come to a shared understanding of key concepts and findings to inform our collective work. No other evidence synthesis was found on this topic and this knowledge is crucial to support the development of our equity-oriented and contextually relevant educational strategies. Although we had conducted previous synthesis work on albinism and human rights (Reimer-Kirkham et al., 2019; Reimer-Kirkham et al., in review), the focus of this current synthesis is distinct as it targets the perinatal period and broadens the scope to health professions education. This synthesis will inform the next phases of our study and gather insights from relevant sources to present a comprehensive synthesis of birthing experiences of mothers, families, and carers to the birth of a baby with albinism in sub-Saharan Africa.