Enhancement of dissolution rate of poorly soluble active ingredients by supercritical fluid processes
- Resource Type
- Authors
- M Perrut; F Leboeuf; J. Jung
- Source
- International Journal of Pharmaceutics. 288:11-16
- Subject
- chemistry.chemical_classification
Active ingredient
Cyclodextrin
chemistry
Composite number
Pharmaceutical Science
Organic chemistry
Nanoparticle
Solubility
Micronization
Dissolution
Supercritical fluid
- Language
- ISSN
- 0378-5173
In this second of two articles, we show that several supercritical processes have been developed to prepare composite particles of poorly soluble active ingredients. Microencapsulation, cyclodextrin inclusion and impregnation allow to incorporate poorly soluble materials in fast-dissolving hydrophilic excipients, leading to promising results in terms of dissolution rate enhancement.