Many studies have demonstrated that drugs, after provoking acute effects on behavior, are better tolerated by subjects that have received repeated administrations of them. The development of tolerance to certain drug effects has been studied in many types of them, including cannabis. A Pavlovian perspective predicts context specificity of tolerance, as this phenomenon is considered partially associative in nature. Of interest, the contextual specificity of tolerance that has been found in many drugs (e.g., ethanol, morphine) has not been yet investigated in cannabis. This project aims to evaluate the acute effects, chronic tolerance, and the contextual specificity of tolerance to the effects of cannabis on motor coordination of adult rats. For this purpose, we will use 24 Sprague-Dawley adult rats, which will be separated into 3 experimental groups (n = 8), divided according to drug concentration exposure (cannabis extract with 0, 75, or 150 mg/ml of THC). Training and testing will be carried out in a rotarod 5 min before and 5 min after the vaporized administration of the drug, measuring time to fall from the rotarod as the dependent variable. Contexts and sex will be counterbalanced between groups. The experiment has three specific aims according to each variable of interest: Specific Objective 1 (SO1): To evaluate and compare between groups the acute effects of cannabis on the motor coordination of adult rats. Specific Objective 2 (SO2): To evaluate and compare between groups the development of chronic cannabis tolerance on the motor coordination of adult rats. Specific Objective 3 (SO3): To evaluate and compare between groups the context specificity of tolerance to the effects of cannabis on the motor coordination of adult rats. Acknowledgment: We are grateful to the National Agency for Research and Development of Chile (ANID-Chile) for supporting the work of the Research Group in Experimental Psychology and Psychopathology, Department of Psychology, Faculty of Social Sciences, University of Chile. This study is funded by project ANID-Fondecyt 1191619 granted to Mario Laborda.