Vitamin D and Tuberculosis
- Resource Type
- Authors
- Adrian R. Martineau; Kirsten Mitchell; Chris Griffiths
- Source
- Subject
- 0301 basic medicine
medicine.medical_specialty
Tuberculosis
biology
business.industry
Disease
Antimicrobial
biology.organism_classification
medicine.disease
World health
Mycobacterium tuberculosis
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Internal medicine
Global health
Vitamin D and neurology
Medicine
Observational study
business
030215 immunology
- Language
Tuberculosis (TB) is a major global health problem: the World Health Organization estimates that there were 9.6 million incident cases and 1.5 million deaths from the disease in 2014. The development of new agents to prevent acquisition or reactivation of latent Mycobacterium tuberculosis infection and to allow shortening of antimicrobial therapy regimens for active TB without loss of efficacy is a research priority. This chapter describes the immunomodulatory actions of vitamin D metabolites in mycobacterial infection and reviews the growing body of evidence from observational and interventional studies suggesting that vitamin D may have a role in the prevention and treatment of TB.