Felodipine enhances aminoglycosides efficacy against implant infections caused by methicillin-resistant Staphylococcus aureus, persisters and biofilms
- Resource Type
- ACADEMIC JOURNAL
- Authors
- Zhang, Shutao a, 1; Qu, Xinhua a, 1; Jiao, Juyang a; Tang, Haozheng a; Wang, Minqi a; Wang, You a; Yang, Hongtao b; Yuan, Weien c; Yue, Bing a, ∗
- Source
- In Bioactive Materials August 2022 14:272-289
- Subject
- Language
- English
- ISSN
- 2452-199X
- E-ISSN
- DOI
- 10.1016/j.bioactmat.2021.11.019
@@@@Highlights •Felodipine inhibits MRSA gene expression associated with aminoglycoside resistance and biofilm formation.•Felodipine eradicates formed biofilm and persisters on the surface of implants.•Felodipine induces proteolysis of MRSA and decreases energy metabolism.•Felodipine in combination with gentamicin alleviates murine periprosthetic joint infection.