TP53 mitigates cisplatin resistance in non-small cell lung cancer by mediating the effects of resistant cell-derived exosome mir-424-5p
- Resource Type
- Article
- Authors
- Deng, Yan ; Ding, Hao ; Zhang, Yanhua ; Feng, Xudong ; Ye, Qing ; Tian, Rui ; Xu, Yuchuan ; He, Qingqing ; Fu, Qiaofen ; Li, Rongqing
- Source
- In Heliyon 15 March 2024 10(5)
- Subject
- Language
- ISSN
- 2405-8440
Conclusion DDP-resistant cell-derived exosome miR-424-5p contributes to NSCLC growth and DDP resistance by targeting SOCS5 and SOCS6 to activate JAK2/STAT3 and PI3K/AKT pathways, which are blocked by TP53.