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Determination of the nanoparticle- and cell-specific toxicological mechanisms in 3D liver spheroids using scRNAseq analysis

Resource Type: ACADEMIC JOURNAL
Authors: Li, Jiulong ^{a, b, 1}; Diamante, Graciel ^{d, 1}; Ahn, In Sook ^d; Wijaya, Darren ^d; Wang, Xiang ^{a, b}; Chang, Chong Hyun ^{a, b}; Ha, Sung-min ^d; Immadisetty, Kavya ^d; Meng, Huan ^{a, b}; Nel, André ^{a, b, ⁎}; Yang, Xia ^{c, d, ⁎⁎}; Xia, Tian ^{a, b, ⁎}
Source: In Nano Today December 2022 47
Subject
Language: English
ISSN: 1748-0132
E-ISSN
DOI: 10.1016/j.nantod.2022.101652

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초록

@@@@Highlights •3D liver spheroid and scRNAseq were used to elucidate nanoparticles’ toxicological mechanisms.•Nanoparticle type- and cell type-specific changes in genes and pathways were identified.•Hepatocytes showed larger numbers of gene expression and pathway changes than Kupper cells.•V2O5 had the strongest negative impacts, followed by GO and TiO2 nanoparticles.

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학술논문

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Determination of the nanoparticle- and cell-specific toxicological mechanisms in 3D liver spheroids using scRNAseq analysis

Online Access

초록