sEVsRVG selectively delivers antiviral siRNA to fetus brain, inhibits ZIKV infection and mitigates ZIKV-induced microcephaly in mouse model
- Resource Type
- ACADEMIC JOURNAL
- Authors
- Zhang, Rui 1, 6; Fu, Yuxuan 4, 6; Cheng, Min 1; Ma, Wenyuan 1; Zheng, Nan 1; Wang, Yongxiang 5, ∗∗; Wu, Zhiwei 1, 2, 3, ∗
- Source
- In Molecular Therapy 4 May 2022 30(5):2078-2091
- Subject
- Language
- English
- ISSN
- 1525-0016
- E-ISSN
- DOI
- 10.1016/j.ymthe.2021.10.009
@@@@R Zhang et al. developed a specific antiviral therapy capable of crossing the placental and blood-brain barriers by designing brain-targeted small extracellular vesicles (sEVs) encapsulating antiviral siRNA (ZIKV specific) to inhibit ZIKV. Their findings suggested that sEVsRVG-siRNA could be a potential therapeutic approach to prevent microcephaly in ZIKV-infected fetal mice during pregnancy.