Hydrogen sulfide protects against cell damage through modulation of PI3K/Akt/Nrf2 signaling
- Resource Type
- ACADEMIC JOURNAL
- Zhang, Jiaxin a, 1; Shi, Chaoqun a, 1; Wang, Haochen a, 1; Gao, Cheng a; Chang, Pan d; Chen, Xiping a; Shan, Haiyan b, ; Zhang, Mingyang a, c, ; Tao, Luyang a
- In International Journal of Biochemistry and Cell Biology December 2019 117
Highlights •Traumatic scratch injury induced ROS production and autophagic cell death in PC12 cells.•Endogenous hydrogen sulfide was involved in the pathophysiology of traumatic scratch induced cell injury.•Exogenous Hydrogen sulfide has yielded positive effect on traumatic scratch-mediated injury.•Exogenous Hydrogen sulfide inhibited oxidative stress and autophagic cell death by modulation of the PI3K/AKT/Nrf2 pathway.