Exploration of novel hexahydropyrrolo[1,2-e]imidazol-1-one derivatives as antiviral agents against ZIKV and USUV
- Resource Type
- ACADEMIC JOURNAL
- Chen, Ran a, e, 1; Francese, Rachele b, 1; Wang, Na c; Li, Feng a; Sun, Xia a; Xu, Bin a; Liu, Jinsong c; Liu, Zhuyun d; Donalisio, Manuela b; Lembo, David b, ∗∗; Zhou, Guo-Chun a, e, ∗
- In European Journal of Medicinal Chemistry 15 February 2023 248
@@@@Highlights •Two hexahydropyrrolo[1,2-e]imidazole-1-one derivatives are anti-flavivirus agents.•Introduction of 2-deoxyribose to 3-arene improves the inhibition of ZIKV and USUV.•ZDL-115 and ZDL-116 are able to reduce the production of infectious viral progeny.•Data suggested that the compounds exert both preventive and therapeutic activity.•Docking analysis showed that VDR and viral proteins are the binders of ZDL-116.